Harnessing migraines for neural regeneration

Harnessing biomechanics to develop cartilage regeneration strategies.

As this review was prepared specifically for the American Society of Mechanical Engineers H.R. Lissner Medal, it primarily discusses work toward cartilage regeneration performed in Dr. Kyriacos A. Athanasiou's laboratory over the past 25 years. The prevalence and severity of degeneration of articular cartilage, a tissue whose main function is largely biomechanical, have motivated the developmen...

Harnessing endogenous stem/progenitor cells for tendon regeneration.

Current stem cell-based strategies for tissue regeneration involve ex vivo manipulation of these cells to confer features of the desired progenitor population. Recently, the concept that endogenous stem/progenitor cells could be used for regenerating tissues has emerged as a promising approach that potentially overcomes the obstacles related to cell transplantation. Here we applied this strateg...

Nanobiomaterials for neural regeneration

Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the ...

Pulp Regeneration by Harnessing Dental Pulp Stem Cells

Migraines in Mice?

an allele of tottering that causes profound chronic ataxia associated with pervasive Purkinje and granule cell loss Department of Neuroscience and Anatomy throughout the anterior cerebellum and reduced cere-Pennsylvania State University College of Medicine bellar size. Like tottering mice, spike and wave dis-Hershey, Pennsylvania 17033 charges have been detected in leaner mice, but the paroxysm...